How Entresto Works: Understanding Heart Failure Treatment

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Heart failure affects millions of people worldwide and is a serious condition that requires effective treatment. One of the notable medications used in heart failure treatment is Entresto. In this article, we will delve into the mechanism of action of Entresto and its role in treating heart failure. Let’s explore how Entresto works to improve the lives of individuals suffering from this condition.

Understanding Heart Failure

Before we dive into the specifics of Entresto, it is crucial to comprehend what heart failure entails. Heart failure occurs when the heart is unable to pump enough blood to meet the body’s demands. This can be due to various factors, including hypertension, coronary artery disease, or a previous heart attack. The consequences of heart failure can be debilitating, leading to symptoms such as fatigue, shortness of breath, and fluid retention.

The Role of Entresto in Heart Failure Treatment

Entresto has emerged as a powerful medication in the treatment of heart failure. It works by inhibiting the harmful effects of a hormone called angiotensin II, which is responsible for constricting blood vessels and causing the heart to work harder. By blocking the action of angiotensin II, Entresto helps dilate blood vessels and reduces the strain on the heart.

The combination of two main components, sacubitril and valsartan, in Entresto allows for a dual mechanism of action. Sacubitril inhibits an enzyme called neprilysin, which breaks down beneficial substances involved in maintaining a healthy cardiovascular system. By blocking neprilysin, sacubitril allows these substances to accumulate, leading to improved heart function and reduced heart failure symptoms. Valsartan, on the other hand, is an angiotensin II receptor blocker, which further aids in preventing blood vessel constriction and reducing the workload on the heart.

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Key Components of Entresto

To better understand the efficacy of Entresto, let’s take a closer look at its key components:


Sacubitril, also known as a neprilysin inhibitor, plays a critical role in the mechanism of action of Entresto. By inhibiting neprilysin, sacubitril prevents the breakdown of substances like natriuretic peptides, which help regulate blood vessel dilation, sodium balance, and fluid volume. This leads to improved heart function and reduced strain on the cardiovascular system.


Valsartan, an angiotensin II receptor blocker, complements sacubitril’s action in Entresto. Angiotensin II is a hormone that causes blood vessels to constrict and increases blood pressure. By blocking the angiotensin II receptor, valsartan prevents these effects, leading to relaxation and dilation of blood vessels. This helps to reduce the workload on the heart and improve overall cardiovascular function.

Frequently Asked Questions (FAQs) about Entresto

Q: Are there any side effects associated with Entresto?

A: Like any medication, Entresto can have side effects. The most common ones include low blood pressure, dizziness, and an increased risk of angioedema. It is essential to discuss potential side effects with your healthcare provider before starting Entresto.

Q: How should Entresto be taken?

A: Entresto is typically taken in tablet form, with the dosage determined by your healthcare provider. It is important to follow the prescribed dosage and instructions provided. Do not stop or change the dosage without consulting your healthcare provider.

Q: Can Entresto interact with other medications?

A: Yes, Entresto may interact with certain medications, including other blood pressure medications, diuretics, and nonsteroidal anti-inflammatory drugs (NSAIDs). It is crucial to inform your healthcare provider about all medications you are taking to avoid potential interactions.

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Entresto has revolutionized heart failure treatment with its unique mechanism of action. By inhibiting neprilysin and blocking the angiotensin II receptor, Entresto helps improve heart function, dilate blood vessels, and reduce strain on the cardiovascular system. This medication offers hope to individuals suffering from heart failure, alleviating symptoms and improving quality of life.

If you or a loved one is experiencing heart failure, consult with your healthcare provider to determine if Entresto is a suitable treatment option. Remember, understanding how Entresto works is crucial in empowering you to make informed decisions regarding your heart health. Together with your healthcare provider, you can navigate the path to a healthier heart and a brighter future.

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